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Alemtuzumab therapy lowers circulating and cerebrospinal immunoglobulin levels in multiple sclerosis

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  • Alemtuzumab therapy reduces immunoglobulin levels in the peripheral blood and cerebrospinal fluid of people with relapsing-remitting multiple sclerosis.

Why this matters

    This study provides Class IV evidence that long-term treatment with alemtuzumab can reduce immunoglobulin levels in relapsing-remitting multiple sclerosis. Prophylactic anti-infectives may be required, particularly in those receiving more than two treatment courses of alemtuzumab.

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