Elevated LDL cholesterol (LDL-C) levels were associated with higher probability of having early onset Alzheimer’s disease (EOAD) and in those with EOAD rare coding variants in APOB (which code for the major protein of LDL-C).
Why this matters
Much is known about the genetic basis of late-onset Alzheimer’s Disease (AD). However, early onset Alzheimer’s disease (EOAD), a rare form of AD, is not well understood.
This study sheds light on the role of LDL-C in EOAD pathogenesis and suggests a direct link of APOB variants and risk of AD, which may be of use in the future identification of at-risk individuals.
Vous souhaitez en lire plus ?
Connectez-vous à votre compte ou inscrivez-vous à Neurodiem pour consulter la suite.
Vous avez déjà un compte ? S'identifier
International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.
No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.