Phase II trial for RPA class V and VI glioblastoma: Hypofractionated radiotherapy vs temozolomide

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  • Hypofractionated radiation therapy provides better progression free survival (PFS) and quality-adjusted survival (QaS) compared to exclusive temozolomide chemotherapy (CHT) without causing significant differences in overall survival (OS).

Why this matters

  • There is a scarcity of studies evaluating quality of life in very poor prognostic classes (RPA V and VI) of glioblastoma patients; these findings support that while both treatments are well tolerated, hypofractionated radiotherapy may lead to better PFS and QaS compared to CHT without a significant difference in OS.

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