Proteotoxicity in amyotrophic lateral sclerosis and frontotemporal dementia

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  • Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) and SET domain-containing protein 8 (SETD8) regulate the clearance of misfolded proteins.

Why this matters

  • L3MBTL1 inhibition could be a potential therapeutic target for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD).

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